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Extracellular Acidosis and inflammation-Argentina/France

The development of acidic environments (or extracellular acidosis) is yet another hallmark of
inflammatory processes of different etiology. Interstitial acidification (pH 5.5–7.0) is commonly
associated with the development of inflammatory reactions against pathogens in peripheral tissues (16,
17, 18, 19, 20, 21). Not only are inflammatory reactions against pathogens associated with the
development of acidic environments, but autoimmune processes such as those in rheumatoid arthritis
and asthma are also associated with the development of acidic microenvironments in injured tissues.
The pH of synovial fluid of compromised joints in patients with rheumatoid arthritis is acidic (pH 6.7–
7.4), and acidosis appears to correlate with ... >> read more/download pdf