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Acid-Base Homeostasis: Latent Acidosis, Cause of Chronic Diseases-Germany

Latest findings on the beneficial disease-modifying aspects of an adequate dietary base supply

Prof Dr Jurgen Vormann, Thomas Goedecke
Institut fur Prävention und Ernährung, DE-Ismaning, Munich - Germany

(Please note: attached, at the tail of the excerpts you will find a link for the full article)

prof-juergenvormann.jpgIn the healthy human being, the blood has a pH value of 7.4. Even slight deviations from this value may lead to severe disturbances in metabolism which may even be life-threatening. It is for this reason that the body`s extensive buffer systems ensure that the blood pH is maintained between the very narrow limits of 7.37 and 7.43. These buffer systems bind and neutralize the additional protons (H+ ions) or hydroxide ions (OH– ions) respectively associated with excessive acidity or alkalinity and thereby prevent them from immediate and marked influences on metabolism. In order to
maintain the optimal metabolic functioning and therefore the buffering capacity on a long-term basis, the organism is also dependent on the constant regeneration of the buffer systems.

Some of the Results: A latent acidosis resulting from a gradual reduction of the buffer reserves, mainly due to nutritional influences, does not produce major changes of blood pH because of compensatory mechanisms through urinary acid excretion. However, there is causal evidence
that this compensation, in the long term, inevitably leads to loss of bone substance and impairs the structure and function of the connective tissue.

- In the past, the pH regulation was taken for granted in persons not being severely ill and the required buffering capacity of the organism was accepted as being virtually inexhaustible.
But today latent acidosis resulting from a gradual reduction of the buffer reserves is increasingly in the focus of interest for the development and progression of chronic diseases such as osteoporosis and rheumatoid disorders......

- Is animal or vegetable protein detrimental to bone health?
Judging from the most recent studies, food protein from different sources seems to have different effects on bone metabolism. Elderly women who have a high proportion of animal protein in their diet showed a more rapid loss of bone density and a higher risk of hip fractures than women with a low proportion. ...

-  study with children: "Protein and alkalising minerals are thus increasingly described as playing a major role in influencing bone status in children and adolescents."

- How does pH of the brain relate to performance and IQ? "Of considerable interest was the
finding, in a study on 42 boys [39], of a significant positive correlation between the pH in the brain and the intelligence quotient (IQ), i.e. the lower the actual acid concentration in the brain, the
higher the IQ."

(... when we support the body to eliminate acidity regularly our IQ will go up.)

- Rheuma, arthritis and acidity: "Effects of latent acidosis on the function of cartilage can be explained in this way. At present, however, the complex structure of the extracellular matrix does not allow direct measurement of the function of cartilaginous tissue with different degrees of dissociation. In patients
with rheumatoid arthritis the pH of the knee joint’s synovial fluid is significantly more acidic compared to the normal range (pH 7.4 – 7.8), as shown in Fig. 13 [30]. Consequently, acidosis
encourages joint cartilage abrasion by mechanical stress that promotes the vicious circle of deformation and inflammation."

- Chronic back pain and connection to acidity:  " Patients with chronic low back pain without radicular involvement benefited
from a 4-week supplementary diet therapy by taking alkaline minerals:
both the pain as well as the physical mobility improved significantly (see Fig. 14), and the consumption of nonsteroidal, anti-inflammatory drugs (NSAID), which may cause severe side effects when applied chronically, could be clearly reduced [31]. Indeed, long term balancing of acids and bases is required for a complete regeneration of the connective tissue and to noticeably relieve the chronic pain."

- Sport and lactic acid issues: "In sportsmen and sportswomen, frequent lactate acidosis increases the susceptibility to physical injury. In contrast, it is suggested that an adequate
base supply may have a beneficial impact on performance by delaying the onset of lactate acidosis but also by avoiding physical impairment. Muscle activity during sports performance is in fact known to be associated with an increase in both intra- and extracellular proton concentration. .... These results accordingly suggest a delayed onset of muscle fatigue and sustained muscle performance by
alkaline sodium citrate ingestion prior to exercise in sports."


and Ionza editing